The workshop, organized in Turin by CPO Piemonte with the Italian Observatory on Screening, together with Gruppo Italiano Screening ColoRetrale (GISCoR), Istituto per lo Studio e la Prevenzione Oncologica (ISPO) and the Fondazione del Piemonte per l'Oncologia, will present results from the PROTEUS study (Turin) and the SAVE study (Florence), on virtual colonoscopy as primary test for colorectal cancer screening, compared with flexible sigmoidoscopy (PROTEUS) and Faecal Immunochemical Test (SAVE).